Cargando…

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling

Accumulating evidence is indicating metformin to possess the potential ability in preventing tumor development and suppressing cancer growth. However, the exact mechanism of its antitumorigenic effects is still not clear. We found that metformin suppressed the ability of cancer to skew macrophage to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiang, Chi-Fu, Chao, Ting-Ting, Su, Yu-Fu, Hsu, Chia-Chen, Chien, Chu-Yen, Chiu, Kuo-Chou, Shiah, Shine-Gwo, Lee, Chien-Hsing, Liu, Shyun-Yeu, Shieh, Yi-Shing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400538/ https://www.ncbi.nlm.nih.gov/pubmed/28157701 http://dx.doi.org/10.18632/oncotarget.14982

Ejemplares similares

YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Malignancy
por: Chien, Chu-Yen, et al.
Publicado: (2021)

The association of betel quid, alcohol, and cigarettes with salivary gland tumor—A case–control study
por: Li, Tsung-I., et al.
Publicado: (2017)

Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy
por: Hsu, Chia-Chen, et al.
Publicado: (2020)

Correction to: Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy
por: Hsu, Chia-Chen, et al.
Publicado: (2020)

Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways
por: Su, Sheng-Chiang, et al.
Publicado: (2019)

Regulation of c-Fos Gene Expression by NF-κB: A p65 Homodimer Binding Site in Mouse Embryonic Fibroblasts but Not Human HEK293 Cells
por: Tu, Yu-Cheng, et al.
Publicado: (2013)

High-Molecular-Weight Hyaluronic Acid Inhibits IL-1β-Induced Synovial Inflammation and Macrophage Polarization through the GRP78-NF-κB Signaling Pathway
por: Lee, Chien-Hsing, et al.
Publicado: (2021)

MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking
por: Peng, Hsuan-Yu, et al.
Publicado: (2020)

MicroRNAs: Their Role in Metabolism, Tumor Microenvironment, and Therapeutic Implications in Head and Neck Squamous Cell Carcinoma
por: Shiah, Shine-Gwo, et al.
Publicado: (2021)

Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis
por: Wang, Chun-Hua, et al.
Publicado: (2017)

Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-κB Signaling Pathway
por: Li, Ling, et al.
Publicado: (2020)

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway
por: Guo, Haohui, et al.
Publicado: (2021)

Plasma Concentrations Predict Aortic Expression of Growth-Arrest-Specific Protein 6 in Patients Undergoing Coronary Artery Bypass Grafting
por: Lee, Chien-Hsing, et al.
Publicado: (2013)

Correction: Plasma Concentrations Predict Aortic Expression of Growth-Arrest-Specific Protein 6 in Patients Undergoing Coronary Artery Bypass Grafting
por: Lee, Chien-Hsing, et al.
Publicado: (2017)

TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility
por: Hsing, En-Wei, et al.
Publicado: (2019)

A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4
por: Chien, Chu-Yen, et al.
Publicado: (2017)

NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes
por: Huang, Kuo-Hsiung, et al.
Publicado: (2014)

Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways
por: Chang, Jui-Shu, et al.
Publicado: (2018)

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
por: Wang, Yu, et al.
Publicado: (2019)

Growth arrest‐specific 6 modulates adiponectin expression and insulin resistance in adipose tissue
por: Su, Sheng‐Chiang, et al.
Publicado: (2020)

AMPK-NF-κB Axis in the Photoreceptor Disorder during Retinal Inflammation
por: Kamoshita, Mamoru, et al.
Publicado: (2014)

Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer
por: Lee, Chien-Hsing, et al.
Publicado: (2010)

Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway
por: Lin, Chien-Liang, et al.
Publicado: (2012)

Metformin Attenuates Osteoporosis in Diabetic Patients with Carcinoma in Situ: A Nationwide, Retrospective, Matched-Cohort Study in Taiwan
por: Lu, Chieh-Hua, et al.
Publicado: (2020)

Disease Caused by Rotavirus Infection
por: Lin, Che-Liang, et al.
Publicado: (2014)

Combination of COX-2 inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan
por: Lu, Chieh-Hua, et al.
Publicado: (2019)

Impact of Metformin Use on Survival in Patients with Gastric Cancer and Diabetes Mellitus Following Gastrectomy
por: Chung, Wai-Shan, et al.
Publicado: (2020)

IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy
por: Tsai, Mei-Lan, et al.
Publicado: (2021)

Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression
por: Zhou, Zhong'e, et al.
Publicado: (2016)

Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-κB Signaling Pathway in Bovine Mammary Epithelial Cells
por: Arbab, Abdelaziz Adam Idriss, et al.
Publicado: (2021)

Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation
por: Chang, Wei-Min, et al.
Publicado: (2017)

CCAL1 enhances osteoarthritis through the NF‐κB/AMPK signaling pathway
por: Zhu, Hanzhong, et al.
Publicado: (2020)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation
por: Lai, Hong-Yue, et al.
Publicado: (2021)

Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1
por: Lee, Chien-Hsing, et al.
Publicado: (2017)

PDIA4, a new endoplasmic reticulum stress protein, modulates insulin resistance and inflammation in skeletal muscle
por: Lee, Chien-Hsing, et al.
Publicado: (2022)

Beyond NF-κB activation: nuclear functions of IκB kinase α
por: Huang, Wei-Chien, et al.
Publicado: (2013)

N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin
por: Kuo, Yueh-Hsiung, et al.
Publicado: (2017)

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis
por: Liu, Bingli, et al.
Publicado: (2023)

New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway
por: Hsu, Sheng-Kai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ck1ai31ttov2o726gn58br2be8