Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo

Elderly and frail patients, diagnosed with acute myeloid leukemia (AML) and ineligible to undergo intensive treatment, have a dismal prognosis. The small molecule inhibitor volasertib induces a mitotic block via inhibition of polo-like kinase 1 and has shown remarkable anti-leukemic activity when co...

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Detalles Bibliográficos
Autores principales: Schnerch, Dominik, Schüler, Julia, Follo, Marie, Felthaus, Julia, Wider, Dagmar, Klingner, Kathrin, Greil, Christine, Duyster, Justus, Engelhardt, Monika, Wäsch, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400573/
https://www.ncbi.nlm.nih.gov/pubmed/28416751
http://dx.doi.org/10.18632/oncotarget.15503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400573/
https://www.ncbi.nlm.nih.gov/pubmed/28416751
http://dx.doi.org/10.18632/oncotarget.15503

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