Cargando…

TGF-β–independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC

Hepatocellular carcinoma (HCC) is resistant to conventional chemotherapeutic agents and remains an unmet medical need. Here, we demonstrate a mechanism of cell adhesion-mediated drug resistance using a variety of HCC spheroid models to overcome environment-mediated drug resistance in HCC. We classif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yeonhwa, Kim, Jin-Sun, Choi, Eun Kyung, Kim, Joon, Kim, Kang Mo, Seo, Haeng Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400613/ https://www.ncbi.nlm.nih.gov/pubmed/28423507 http://dx.doi.org/10.18632/oncotarget.15521

Ejemplares similares

Oxytetracycline have the therapeutic efficiency in CD133(+) HCC population through suppression CD133 expression by decreasing of protein stability of CD133
por: Song, Yeonhwa, et al.
Publicado: (2018)

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes
por: Jang, Jae-Woo, et al.
Publicado: (2016)

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids
por: Song, Yeonhwa, et al.
Publicado: (2016)

TGF-β Regulates Collagen Type I Expression in Myoblasts and Myotubes via Transient Ctgf and Fgf-2 Expression
por: Hillege, Michèle M. G., et al.
Publicado: (2020)

Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
por: Wang, Qingjian, et al.
Publicado: (2011)

Ets-1 Is Essential for Connective Tissue Growth Factor (CTGF/CCN2) Induction by TGF-β1 in Osteoblasts
por: Geisinger, Max T., et al.
Publicado: (2012)

GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models
por: Kim, Se-Hyuk, et al.
Publicado: (2019)

Glucocorticoids activate TGF-β induced PAI-1 and CTGF expression in rat hepatocytes
por: Wickert, Lucia, et al.
Publicado: (2007)

Expression levels of TGF-β1 and CTGF are associated with the severity of Duchenne muscular dystrophy
por: Song, Yanmin, et al.
Publicado: (2017)

STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression
por: Makino, Yuki, et al.
Publicado: (2022)

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1
por: Yoon, Hyun Joo, et al.
Publicado: (2015)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling
por: Shin, Wookjin, et al.
Publicado: (2018)

BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells
por: Chen, Po-Jen, et al.
Publicado: (2020)

Human Epicardial Adipose Tissue cTGF Expression is an Independent Risk Factor for Atrial Fibrillation and Highly Associated with Atrial Fibrosis
por: Wang, Qing, et al.
Publicado: (2018)

Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells
por: Zuehlke, Jonathan, et al.
Publicado: (2012)

Caffeine and Rolipram Affect Smad Signalling and TGF-β1 Stimulated CTGF and Transgelin Expression in Lung Epithelial Cells
por: Fehrholz, Markus, et al.
Publicado: (2014)

Lower expression of Hsa_circRNA_102682 in diabetic hyperhomocysteinemia negatively related to creatinemia is associated with TGF‐β and CTGF
por: Hu, Fei, et al.
Publicado: (2021)

CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma
por: Dillinger, Andrea E., et al.
Publicado: (2023)

Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells
por: Song, Yeonhwa, et al.
Publicado: (2017)

PPARδ promotes wound healing by up-regulating TGF-β1-dependent or -independent expression of extracellular matrix proteins
por: Ham, Sun Ah, et al.
Publicado: (2010)

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes
por: Seo, Hye-Young, et al.
Publicado: (2022)

Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism
por: Guo, Fen, et al.
Publicado: (2011)

Inhibition of angiogenesis by arsenic trioxide via TSP-1–TGF-β1-CTGF–VEGF functional module in rheumatoid arthritis
por: Zhang, Juan, et al.
Publicado: (2017)

Near-infrared-emitting nanoparticles activate collagen synthesis via TGFβ signaling
por: Kang, Myung Hyun, et al.
Publicado: (2020)

Induction of Ovarian Primordial Follicle Assembly by Connective Tissue Growth Factor CTGF
por: Schindler, Ryan, et al.
Publicado: (2010)

TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways
por: Ou, Shu-Ching, et al.
Publicado: (2020)

TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation
por: Faherty, Noel, et al.
Publicado: (2013)

TGFβ1 and HGF regulate CTGF expression in human atrial fibroblasts and are involved in atrial remodelling in patients with rheumatic heart disease
por: Chen, Jian‐Quan, et al.
Publicado: (2019)

Recombinant human endostatin combined with radiotherapy promotes cardiomyocyte apoptosis in rats via TGFβ1/Smads/CTGF signaling pathway
por: Ouyang, Weiwei, et al.
Publicado: (2022)

Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH
por: Lee, Su-Yeon, et al.
Publicado: (2022)

Dynamic Malignant Wave of Ribosome-Insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit
por: Kim, Ki Hyung, et al.
Publicado: (2020)

Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment
por: Dituri, Francesco, et al.
Publicado: (2021)

Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes
por: Nagaraja, Tirumuru, et al.
Publicado: (2012)

TGF‐β Initiates β‐Catenin‐Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration
por: Wu, Qiuqian, et al.
Publicado: (2018)

Sustained Induction of Collagen Synthesis by TGF-β Requires Regulated Intramembrane Proteolysis of CREB3L1
por: Chen, Qiuyue, et al.
Publicado: (2014)

FUNCTIONAL CELL PHENOTYPE INDUCTION WITH TGF-β1 AND COLLAGEN-POLYURETHANE SCAFFOLD FOR ANNULUS FIBROSUS RUPTURE REPAIR
por: Du, J., et al.
Publicado: (2020)

HO-1089 and HO-1197, Novel Herbal Formulas, Have Antitumor Effects via Suppression of PLK1 (Polo-like Kinase 1) Expression in Hepatocellular Carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2023)

AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression
por: Lee, Saerom, et al.
Publicado: (2021)

Adiponectin, but Not TGF-β1, CTGF, IL-6 or TNF-α, May Be a Potential Anti-Inflammation and Anti-Fibrosis Factor in Keloid
por: Luo, Limin, et al.
Publicado: (2021)

The effects of docetaxel and/or captopril in expression of TGF-β1, MMP-1, CTGF, and PAI-1 as markers of anterior urethral stricture in an animal model
por: Kurniawan, Wikan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_67pcto3tigjq4u6vvjebje78k5