HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis

Immunotoxin 4D5scFv-PE40 is a recombinant protein that comprises 4D5scFv antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector (toxic) one. The immunotoxin has shown pronounced antitumor effect on cancer cells overexpressing HER2 receptor in vitro and on HER2-positive...

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Detalles Bibliográficos
Autores principales: Sokolova, Evgeniya, Guryev, Evgeniy, Yudintsev, Andrey, Vodeneev, Vladimir, Deyev, Sergey, Balalaeva, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400645/
https://www.ncbi.nlm.nih.gov/pubmed/28423549
http://dx.doi.org/10.18632/oncotarget.15833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400645/
https://www.ncbi.nlm.nih.gov/pubmed/28423549
http://dx.doi.org/10.18632/oncotarget.15833

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