Genetic Otx2 mis-localization delays critical period plasticity across brain regions

Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan-recognition motif of Otx2 broadly delays the maturation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Henry Hing Cheong, Bernard, Clémence, Ye, Zhanlei, Acampora, Dario, Simeone, Antonio, Prochiantz, Alain, Di Nardo, Ariel A, Hensch, Takao K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400722/
https://www.ncbi.nlm.nih.gov/pubmed/28194008
http://dx.doi.org/10.1038/mp.2017.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400722/
https://www.ncbi.nlm.nih.gov/pubmed/28194008
http://dx.doi.org/10.1038/mp.2017.1

Ejemplares similares