Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats

A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 day...

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Detalles Bibliográficos
Autores principales: Guarnieri, M., Brayton, C., Sarabia-Estrada, R., Tyler, B., McKnight, P., DeTolla, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401735/
https://www.ncbi.nlm.nih.gov/pubmed/28492060
http://dx.doi.org/10.1155/2017/3102567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401735/
https://www.ncbi.nlm.nih.gov/pubmed/28492060
http://dx.doi.org/10.1155/2017/3102567

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