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Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats
A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 day...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401735/ https://www.ncbi.nlm.nih.gov/pubmed/28492060 http://dx.doi.org/10.1155/2017/3102567 |