Quality of TCR signaling encoded by differential enhancer affinities for the composite BATF-IRF4 transcription factor complex

Variable strengths of T cell receptor (TCR) signaling can produce divergent outcomes, but the mechanism remains obscure. The abundance of the transcription factor IRF4 increases with TCR signal strength, but how this would induce distinct types of responses is unclear. We compared T(H)2 gene express...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwata, Arifumi, Durai, Vivek, Tussiwand, Roxane, Briseño, Carlos G., Wu, Xiaodi, Grajales-Reyes, Gary E., Egawa, Takeshi, Murphy, Theresa L., Murphy, Kenneth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401770/
https://www.ncbi.nlm.nih.gov/pubmed/28346410
http://dx.doi.org/10.1038/ni.3714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401770/
https://www.ncbi.nlm.nih.gov/pubmed/28346410
http://dx.doi.org/10.1038/ni.3714

Ejemplares similares