Discovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics

Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) are two key enzymes that drive the efficient biosynthesis of TUDCA from taurochenodeoxycholic acid (TCDCA) in vitro. In this stu...

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Detalles Bibliográficos
Autores principales: Song, Can, Wang, Bochu, Tan, Jun, Zhu, Liancai, Lou, Deshuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402301/
https://www.ncbi.nlm.nih.gov/pubmed/28436439
http://dx.doi.org/10.1038/srep45495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402301/
https://www.ncbi.nlm.nih.gov/pubmed/28436439
http://dx.doi.org/10.1038/srep45495

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