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Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines

Inhibitory A type γ-aminobutyric acid receptors (GABA(A)Rs) play a pivotal role in orchestrating various brain functions and represent an important molecular target in neurological and psychiatric diseases, necessitating the need for the discovery and development of novel modulators. Here, we show t...

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Detalles Bibliográficos
Autores principales: Liu, Yan-Mei, Fan, Hui-Ran, Ding, Jing, Huang, Chen, Deng, Shining, Zhu, Tailin, Xu, Tian-Le, Ge, Wei-Hong, Li, Wei-Guang, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402396/
https://www.ncbi.nlm.nih.gov/pubmed/28436443
http://dx.doi.org/10.1038/srep46654