Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein–DNA Complex

[Image: see text] Metal ion cofactors can alter the energetics and specificity of sequence specific protein–DNA interactions, but it is unknown if the underlying effects on structure and dynamics are local or dispersed throughout the protein–DNA complex. This work uses EcoRV endonuclease as a model,...

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Detalles Bibliográficos
Autores principales: Sinha, Kaustubh, Sangani, Sahil S., Kehr, Andrew D., Rule, Gordon S., Jen-Jacobson, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402698/
https://www.ncbi.nlm.nih.gov/pubmed/27786446
http://dx.doi.org/10.1021/acs.biochem.6b00919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402698/
https://www.ncbi.nlm.nih.gov/pubmed/27786446
http://dx.doi.org/10.1021/acs.biochem.6b00919

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