Primidone inhibits TRPM3 and attenuates thermal nociception in vivo

The melastatin-related transient receptor potential (TRP) channel TRPM3 is a nonselective cation channel expressed in nociceptive neurons and activated by heat. Because TRPM3-deficient mice show inflammatory thermal hyperalgesia, pharmacological inhibition of TRPM3 may exert antinociceptive properti...

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Detalles Bibliográficos
Autores principales: Krügel, Ute, Straub, Isabelle, Beckmann, Holger, Schaefer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402713/
https://www.ncbi.nlm.nih.gov/pubmed/28106668
http://dx.doi.org/10.1097/j.pain.0000000000000846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402713/
https://www.ncbi.nlm.nih.gov/pubmed/28106668
http://dx.doi.org/10.1097/j.pain.0000000000000846

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