siRNA-loaded poly(histidine-arginine)(6)-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis

An ideal carrier that delivers small interfering RNA (siRNA) should be designed based on two criteria: cellular-mediated internalization and endosomal escape. Poly(histidine-arginine)(6)(H6R6) peptide was introduced into chitosan (CS) to create a new CS derivative for siRNA delivery, 6-polyarginine...

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Detalles Bibliográficos
Autores principales: Sun, Ping, Huang, Wei, Kang, Lin, Jin, Mingji, Fan, Bo, Jin, Hongyan, Wang, Qi-Ming, Gao, Zhonggao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402910/
https://www.ncbi.nlm.nih.gov/pubmed/28458542
http://dx.doi.org/10.2147/IJN.S129436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402910/
https://www.ncbi.nlm.nih.gov/pubmed/28458542
http://dx.doi.org/10.2147/IJN.S129436

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