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siRNA-loaded poly(histidine-arginine)(6)-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis

An ideal carrier that delivers small interfering RNA (siRNA) should be designed based on two criteria: cellular-mediated internalization and endosomal escape. Poly(histidine-arginine)(6)(H6R6) peptide was introduced into chitosan (CS) to create a new CS derivative for siRNA delivery, 6-polyarginine...

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Detalles Bibliográficos
Autores principales:	Sun, Ping, Huang, Wei, Kang, Lin, Jin, Mingji, Fan, Bo, Jin, Hongyan, Wang, Qi-Ming, Gao, Zhonggao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402910/ https://www.ncbi.nlm.nih.gov/pubmed/28458542 http://dx.doi.org/10.2147/IJN.S129436

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