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Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes

Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does not halt the autoimmune process; therefore, development of immunotherapies aiming to preserve the residual hormonal cells, is of crucial impor...

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Detalles Bibliográficos
Autores principales:	Perri, Valentina, Pellegrino, Marsha, Ceccacci, Francesca, Scipioni, Anita, Petrini, Stefania, Gianchecchi, Elena, Lo Russo, Anna, De Santis, Serena, Mancini, Giovanna, Fierabracci, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402975/ https://www.ncbi.nlm.nih.gov/pubmed/28437437 http://dx.doi.org/10.1371/journal.pone.0175784

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