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Amino acid composition predicts prion activity

Many prion-forming proteins contain glutamine/asparagine (Q/N) rich domains, and there are conflicting opinions as to the role of primary sequence in their conversion to the prion form: is this phenomenon driven primarily by amino acid composition, or, as a recent computational analysis suggested, d...

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Detalles Bibliográficos
Autores principales: Afsar Minhas, Fayyaz ul Amir, Ross, Eric D., Ben-Hur, Asa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402983/
https://www.ncbi.nlm.nih.gov/pubmed/28394888
http://dx.doi.org/10.1371/journal.pcbi.1005465