The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, a PIKfyve inhibitor that was reported to be well tolerated in...

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Detalles Bibliográficos
Autores principales: Nelson, Elizabeth A., Dyall, Julie, Hoenen, Thomas, Barnes, Alyson B., Zhou, Huanying, Liang, Janie Y., Michelotti, Julia, Dewey, William H., DeWald, Lisa Evans, Bennett, Richard S., Morris, Patrick J., Guha, Rajarshi, Klumpp-Thomas, Carleen, McKnight, Crystal, Chen, Yu-Chi, Xu, Xin, Wang, Amy, Hughes, Emma, Martin, Scott, Thomas, Craig, Jahrling, Peter B., Hensley, Lisa E., Olinger, Gene G., White, Judith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402990/
https://www.ncbi.nlm.nih.gov/pubmed/28403145
http://dx.doi.org/10.1371/journal.pntd.0005540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402990/
https://www.ncbi.nlm.nih.gov/pubmed/28403145
http://dx.doi.org/10.1371/journal.pntd.0005540

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