Identification of capsazepine as a novel inhibitor of system x(c)(−) and cancer-induced bone pain

The cystine/glutamate antiporter has been implicated in a variety of cancers as a major mediator of redox homeostasis. The excess glutamate secreted by this transporter in aggressive cancer cells has been associated with cancer-induced bone pain (CIBP) from distal breast cancer metastases. High-thro...

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Detalles Bibliográficos
Autores principales: Fazzari, Jennifer, Balenko, Matthew D, Zacal, Natalie, Singh, Gurmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402992/
https://www.ncbi.nlm.nih.gov/pubmed/28458574
http://dx.doi.org/10.2147/JPR.S125045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402992/
https://www.ncbi.nlm.nih.gov/pubmed/28458574
http://dx.doi.org/10.2147/JPR.S125045

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