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Identification of capsazepine as a novel inhibitor of system x(c)(−) and cancer-induced bone pain
The cystine/glutamate antiporter has been implicated in a variety of cancers as a major mediator of redox homeostasis. The excess glutamate secreted by this transporter in aggressive cancer cells has been associated with cancer-induced bone pain (CIBP) from distal breast cancer metastases. High-thro...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402992/ https://www.ncbi.nlm.nih.gov/pubmed/28458574 http://dx.doi.org/10.2147/JPR.S125045 |