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Frequent exchange of the DNA polymerase during bacterial chromosome replication

The replisome is a multiprotein machine that carries out DNA replication. In Escherichia coli, a single pair of replisomes is responsible for duplicating the entire 4.6 Mbp circular chromosome. In vitro studies of reconstituted E. coli replisomes have attributed this remarkable processivity to the h...

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Detalles Bibliográficos
Autores principales: Beattie, Thomas R, Kapadia, Nitin, Nicolas, Emilien, Uphoff, Stephan, Wollman, Adam JM, Leake, Mark C, Reyes-Lamothe, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403216/
https://www.ncbi.nlm.nih.gov/pubmed/28362256
http://dx.doi.org/10.7554/eLife.21763