Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance

FOXO3a and FOXM1 are two forkhead transcription factors with antagonistic roles in cancer and DNA damage response. FOXO3a functions like a typical tumour suppressor, whereas FOXM1 is a potent oncogene aberrantly overexpressed in genotoxic resistant cancers. FOXO3a not only represses FOXM1 expression...

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Detalles Bibliográficos
Autores principales: Nestal de Moraes, Gabriela, Bella, Laura, Zona, Stefania, Burton, Matthew J., Lam, Eric W.-F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403963/
https://www.ncbi.nlm.nih.gov/pubmed/25418858
http://dx.doi.org/10.2174/1389450115666141122211549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403963/
https://www.ncbi.nlm.nih.gov/pubmed/25418858
http://dx.doi.org/10.2174/1389450115666141122211549

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