Cargando…

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance

FOXO3a and FOXM1 are two forkhead transcription factors with antagonistic roles in cancer and DNA damage response. FOXO3a functions like a typical tumour suppressor, whereas FOXM1 is a potent oncogene aberrantly overexpressed in genotoxic resistant cancers. FOXO3a not only represses FOXM1 expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nestal de Moraes, Gabriela, Bella, Laura, Zona, Stefania, Burton, Matthew J., Lam, Eric W.-F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403963/ https://www.ncbi.nlm.nih.gov/pubmed/25418858 http://dx.doi.org/10.2174/1389450115666141122211549

Ejemplares similares

FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
por: Zona, Stefania, et al.
Publicado: (2014)

The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors
por: De Moraes, Gabriela Nestal, et al.
Publicado: (2019)

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
por: Yao, Shang, et al.
Publicado: (2018)

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
por: Khongkow, Pasarat, et al.
Publicado: (2013)

FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance
por: Intuyod, Kitti, et al.
Publicado: (2018)

Retraction Note to: FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance
por: Intuyod, Kitti, et al.
Publicado: (2021)

SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells
por: Nestal de Moraes, Gabriela, et al.
Publicado: (2018)

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
por: Gomes, Ana R., et al.
Publicado: (2013)

Cardamonin Promotes the Apoptosis and Chemotherapy Sensitivity to Gemcitabine of Pancreatic Cancer Through Modulating the FOXO3a-FOXM1 Axis
por: Sun, Huapeng, et al.
Publicado: (2021)

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer
por: Karadedou, Christina T., et al.
Publicado: (2011)

Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells
por: Alasiri, Glowi, et al.
Publicado: (2019)

Genotoxicity, DNA damage and sperm defects induced by vinblastine
por: Fahmy, Maha A., et al.
Publicado: (2022)

Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis
por: Ghosh, Sweta, et al.
Publicado: (2022)

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics
por: Tabnak, Peyman, et al.
Publicado: (2023)

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer
por: de Moraes, G Nestal, et al.
Publicado: (2015)

SUMOylation inhibits FOXM1 activity and delays mitotic transition
por: Myatt, S S, et al.
Publicado: (2014)

Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage
por: Halasi, Marianna, et al.
Publicado: (2012)

MiR-4521 perturbs FOXM1-mediated DNA damage response in breast cancer
por: Kuthethur, Raviprasad, et al.
Publicado: (2023)

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells
por: Yang, N, et al.
Publicado: (2017)

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance
por: Karunarathna, U, et al.
Publicado: (2016)

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment
por: Kongsema, M, et al.
Publicado: (2016)

The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma
por: Dibb, M, et al.
Publicado: (2012)

FOXK2 Transcription Factor and Its Emerging Roles in Cancer
por: Nestal de Moraes, Gabriela, et al.
Publicado: (2019)

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells
por: Marchand, Benoît, et al.
Publicado: (2019)

Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a
por: JIANG, LING, et al.
Publicado: (2013)

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress
por: Umar, Sheikh Ahmad, et al.
Publicado: (2020)

Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress
por: Ho, Kathleen, et al.
Publicado: (2021)

Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers
por: Liu, Jun, et al.
Publicado: (2021)

FOXM1 is critical for the fitness recovery of chromosomally unstable cells
por: Pan, Fan, et al.
Publicado: (2023)

EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer
por: Mahmud, Zimam, et al.
Publicado: (2019)

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress
por: Wakida, Takeshi, et al.
Publicado: (2017)

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
por: Miglani, Kanika, et al.
Publicado: (2021)

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
por: Cui, Qiuxia, et al.
Publicado: (2023)

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
por: Yung, Mingo Ming Ho, et al.
Publicado: (2013)

The prion protein is critical for DNA repair and cell survival after genotoxic stress
por: Bravard, Anne, et al.
Publicado: (2015)

Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.
por: Manning, F C, et al.
Publicado: (1994)

Genotoxicity of Tri- and Hexavalent Chromium Compounds In Vivo and Their Modes of Action on DNA Damage In Vitro
por: Fang, Zhijia, et al.
Publicado: (2014)

Next generation high throughput DNA damage detection platform for genotoxic compound screening
por: Sykora, Peter, et al.
Publicado: (2018)

ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
por: Koh, Javier, et al.
Publicado: (2019)

The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells
por: Hou, Youxiang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h8482e9c6136e4g1199j6uldrj