Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

Adoptive transfer of genetically engineered human cells secreting bispecific T-cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging immunotherapeutic strategy will be critical to its s...

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Detalles Bibliográficos
Autores principales: Mølgaard, K, Compte, M, Nuñez-Prado, N, Harwood, S L, Sanz, L, Alvarez-Vallina, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404205/
https://www.ncbi.nlm.nih.gov/pubmed/28075428
http://dx.doi.org/10.1038/gt.2017.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404205/
https://www.ncbi.nlm.nih.gov/pubmed/28075428
http://dx.doi.org/10.1038/gt.2017.3

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