Cargando…

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

Adoptive transfer of genetically engineered human cells secreting bispecific T-cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging immunotherapeutic strategy will be critical to its s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mølgaard, K, Compte, M, Nuñez-Prado, N, Harwood, S L, Sanz, L, Alvarez-Vallina, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404205/ https://www.ncbi.nlm.nih.gov/pubmed/28075428 http://dx.doi.org/10.1038/gt.2017.3

Ejemplares similares

DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents
por: Chooniedass, Shilpa, et al.
Publicado: (2016)

Functional Domain Order of an Anti-EGFR × Anti-CD16 Bispecific Diabody Involving NK Cell Activation
por: Kuwahara, Atsushi, et al.
Publicado: (2020)

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity
por: Asano, Ryutaro, et al.
Publicado: (2018)

Generation and Characterization of a Diabody Targeting the α(v)β(6) Integrin
por: Kogelberg, Heide, et al.
Publicado: (2013)

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats
por: Asano, Ryutaro, et al.
Publicado: (2020)

Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy
por: Yuan, Qingyun, et al.
Publicado: (2021)

Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.
por: Adams, G. P., et al.
Publicado: (1998)

Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer
por: Cai, Yaxiong, et al.
Publicado: (2017)

Fermentation, Purification, and Tumor Inhibition of a Disulfide-Stabilized Diabody Against Fibroblast Growth Factor-2
por: Zhang, Simin, et al.
Publicado: (2021)

Crystal structures of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface
por: Kim, Jin Hong, et al.
Publicado: (2016)

Distinguishing Between Monomeric scFv and Diabody in Solution Using Light and Small Angle X-ray Scattering
por: Lüdel, Frank, et al.
Publicado: (2019)

Construction of a disulfide‐stabilized diabody against fibroblast growth factor‐2 and the inhibition activity in targeting breast cancer
por: Cai, Yaxiong, et al.
Publicado: (2016)

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies
por: Mikkelsen, Kasper, et al.
Publicado: (2019)

Expression, purification, and characterization of a diabody against the most important angiogenesis cell receptor: Vascular endothelial growth factor receptor 2
por: Behdani, Mahdi, et al.
Publicado: (2012)

Construction of tandem diabody (IL-6/CD20)-secreting human umbilical cord mesenchymal stem cells and its experimental treatment on diffuse large B cell lymphoma
por: Zhang, Jiayi, et al.
Publicado: (2022)

A bispecific diabody directed against prostate-specific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells
por: Bühler, P., et al.
Publicado: (2007)

First clinical study of a pegylated diabody (124)I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers
por: Scott, Andrew M., et al.
Publicado: (2020)

Positron emission tomography imaging with (89)Zr-labeled anti-CD8 cys-diabody reveals CD8(+) cell infiltration during oncolytic virus therapy in a glioma murine model
por: Kasten, Benjamin B., et al.
Publicado: (2021)

Design and preclinical evaluation of a (99m)Tc-labelled diabody of mAb J591 for SPECT imaging of prostate-specific membrane antigen (PSMA)
por: Kampmeier, Florian, et al.
Publicado: (2014)

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics
por: Asano, Ryutaro, et al.
Publicado: (2014)

Author Correction: Positron emission tomography imaging with (89)Zr-labeled anti-CD8 cys-diabody reveals CD8(+) cell infiltration during oncolytic virus therapy in a glioma murine model
por: Kasten, Benjamin B., et al.
Publicado: (2021)

Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo
por: Xiong, Chenghao, et al.
Publicado: (2018)

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications
por: Compte, Marta, et al.
Publicado: (2014)

A chlorambucil-anti-CEA conjugate cytotoxic for human colon adenocarcinoma cells in vitro.
por: Bernier, L. G., et al.
Publicado: (1984)

A vindesine-anti-CEA conjugate cytotoxic for human cancer cells in vitro.
por: Johnson, J. R., et al.
Publicado: (1981)

Immunotherapeutic organoids: A new approach to cancer treatment
por: Compte, Marta, et al.
Publicado: (2013)

The site of binding of anti-CEA antibodies to tumour CEA in vivo: an immunocytochemical and autoradiographic approach.
por: Moshakis, V., et al.
Publicado: (1982)

Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine
por: Cha, Seung E., et al.
Publicado: (2021)

The effect of serum CEA on the distribution and clearance of anti-CEA antibody in a pancreatic tumour xenograft model.
por: Pedley, R. B., et al.
Publicado: (1989)

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim
por: Graczyk, Filip, et al.
Publicado: (2022)

Reply: In vitro and in vivo anticancer efficacy of unconjugated humanised anti-CEA monoclonal antibodies
por: Ashraf, S Q, et al.
Publicado: (2008)

Comparison of anti-fetal colonic microvillus and anti-CEA antibodies in peroperative radioimmunolocalisation of colorectal cancer.
por: Blair, S. D., et al.
Publicado: (1990)

Antioxidant, Anti-Inflammatory, and Cytotoxic Properties and Chemical Compositions of Filipendula palmata (Pall.) Maxim.
por: Zhang, Hongyin, et al.
Publicado: (2021)

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris
por: Blanco-Toribio, Ana, et al.
Publicado: (2014)

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts
por: Lázaro-Gorines, R., et al.
Publicado: (2019)

Role of nucleotide‐binding oligomerization domain 1 (NOD1) in pericyte‐mediated vascular inflammation
por: Navarro, Rocío, et al.
Publicado: (2016)

Decrypted secrets: methods and maxims of cryptology
por: Bauer, Friedrich L
Publicado: (2002)

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
por: Blanco, Belén, et al.
Publicado: (2022)

In vitro and in vivo anticancer efficacy of unconjugated humanised anti-CEA monoclonal antibodies
por: Blumenthal, R D, et al.
Publicado: (2008)

Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer
por: da Paz, Mariana Campos, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_et2sl9pkfcpbukgmp8v1f1d8v2