Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects

Injecting proteins into the central nervous system that stimulate neuronal growth can lead to beneficial effects in animal models of disease. In particular, glial cell line-derived neurotrophic factor (GDNF) has shown promise in animal and cell models of Parkinson's disease, Huntington's d...

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Detalles Bibliográficos
Autores principales: Thomsen, G M, Alkaslasi, M, Vit, J-P, Lawless, G, Godoy, M, Gowing, G, Shelest, O, Svendsen, C N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://www.ncbi.nlm.nih.gov/pubmed/28276446
http://dx.doi.org/10.1038/gt.2017.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404206/
https://www.ncbi.nlm.nih.gov/pubmed/28276446
http://dx.doi.org/10.1038/gt.2017.9

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