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Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD
BACKGROUND: Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404321/ https://www.ncbi.nlm.nih.gov/pubmed/28450970 http://dx.doi.org/10.1186/s13148-017-0341-7 |