Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

BACKGROUND: Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, J., Heijink, I. H., Kistemaker, L. E. M., Reinders-Luinge, M., Kooistra, W., Noordhoek, J. A., Gosens, R., Brandsma, C. A., Timens, W., Hiemstra, P. S., Rots, M. G., Hylkema, M. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404321/
https://www.ncbi.nlm.nih.gov/pubmed/28450970
http://dx.doi.org/10.1186/s13148-017-0341-7

Ejemplares similares

Ejemplares similares