Engineering Nucleotide Specificity of Succinyl-CoA Synthetase in Blastocystis: The Emerging Role of Gatekeeper Residues

[Image: see text] Charged, solvent-exposed residues at the entrance to the substrate binding site (gatekeeper residues) produce electrostatic dipole interactions with approaching substrates, and control their access by a novel mechanism called “electrostatic gatekeeper effect”. This proof-of-concept...

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Detalles Bibliográficos
Autores principales: Vashisht, Kapil, Verma, Sonia, Gupta, Sunita, Lynn, Andrew M., Dixit, Rajnikant, Mishra, Neelima, Valecha, Neena, Hamblin, Karleigh A., Maytum, Robin, Pandey, Kailash C., van der Giezen, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404824/
https://www.ncbi.nlm.nih.gov/pubmed/27478903
http://dx.doi.org/10.1021/acs.biochem.6b00098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404824/
https://www.ncbi.nlm.nih.gov/pubmed/27478903
http://dx.doi.org/10.1021/acs.biochem.6b00098

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