Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

BACKGROUND: Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality i...

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Detalles Bibliográficos
Autores principales: Anderson, Letícia, Gomes, Monete Rajão, daSilva, Lucas Ferreira, Pereira, Adriana da Silva Andrade, Mourão, Marina M., Romier, Christophe, Pierce, Raymond, Verjovski-Almeida, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404884/
https://www.ncbi.nlm.nih.gov/pubmed/28406899
http://dx.doi.org/10.1371/journal.pntd.0005539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404884/
https://www.ncbi.nlm.nih.gov/pubmed/28406899
http://dx.doi.org/10.1371/journal.pntd.0005539

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