Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show that PERK signaling is a component of the...

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Detalles Bibliográficos
Autores principales: Larhammar, Martin, Huntwork-Rodriguez, Sarah, Jiang, Zhiyu, Solanoy, Hilda, Sengupta Ghosh, Arundhati, Wang, Bei, Kaminker, Joshua S, Huang, Kevin, Eastham-Anderson, Jeffrey, Siu, Michael, Modrusan, Zora, Farley, Madeline M, Tessier-Lavigne, Marc, Lewcock, Joseph W, Watkins, Trent A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404924/
https://www.ncbi.nlm.nih.gov/pubmed/28440222
http://dx.doi.org/10.7554/eLife.20725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404924/
https://www.ncbi.nlm.nih.gov/pubmed/28440222
http://dx.doi.org/10.7554/eLife.20725

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