Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). However, oxygen is an essential cofactor for mam...

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Detalles Bibliográficos
Autores principales: Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily, Hammond, Ester M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405111/
https://www.ncbi.nlm.nih.gov/pubmed/28416140
http://dx.doi.org/10.1016/j.molcel.2017.03.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405111/
https://www.ncbi.nlm.nih.gov/pubmed/28416140
http://dx.doi.org/10.1016/j.molcel.2017.03.005

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