Cargando…

An optimal stratified Simon two‐stage design

In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. Such targeted trials require designs that allow for stratification based on the participants' molecular characterisation. A targeted design proposed by Jones and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parashar, Deepak, Bowden, Jack, Starr, Colin, Wernisch, Lorenz, Mander, Adrian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Main Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405342/ https://www.ncbi.nlm.nih.gov/pubmed/26932771 http://dx.doi.org/10.1002/pst.1742

Ejemplares similares

Adaptive enrichment in biomarker-stratified clinical trial design
por: Parashar, Deepak, et al.
Publicado: (2013)

Type I error control in biomarker-stratified clinical trials
por: Parashar, Deepak, et al.
Publicado: (2015)

A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials
por: Bowden, J, et al.
Publicado: (2014)

Response‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?
por: Villar, Sofía S., et al.
Publicado: (2017)

A novel equivalence probability weighted power prior for using historical control data in an adaptive clinical trial design: A comparison to standard methods
por: Bennett, Maxine, et al.
Publicado: (2021)

Escalation strategies for combination therapy Phase I trials
por: Sweeting, Michael J, et al.
Publicado: (2012)

Do single‐arm trials have a role in drug development plans incorporating randomised trials?
por: Grayling, Michael J., et al.
Publicado: (2015)

Optimal composite scores for longitudinal clinical trials under the linear mixed effects model
por: Ard, M. Colin, et al.
Publicado: (2015)

Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies
por: Austin, Peter C
Publicado: (2011)

A confidence function‐based posterior probability design for phase II cancer trials
por: Shan, Minghua
Publicado: (2020)

CUSUMIN: A cumulative sum interval design for cancer phase I dose finding studies
por: Hatayama, Tomoyoshi, et al.
Publicado: (2022)

Should the two‐trial paradigm still be the gold standard in drug assessment?
por: Zhan, Stella Jinran, et al.
Publicado: (2022)

Delayed treatment effects, treatment switching and heterogeneous patient populations: How to design and analyze RCTs in oncology
por: Ristl, Robin, et al.
Publicado: (2020)

Modified Simon’s minimax and optimal two-stage designs for single-arm phase II cancer clinical trials
por: Kim, Jongphil, et al.
Publicado: (2019)

Why are two mistakes not worse than one? A proposal for controlling the expected number of false claims
por: Jaki, Thomas, et al.
Publicado: (2016)

SCI: A Bayesian adaptive phase I/II dose‐finding design accounting for semi‐competing risks outcomes for immunotherapy trials
por: Zhang, Yifei, et al.
Publicado: (2022)

A compassionate imagery intervention for patients with persecutory delusions
por: Forkert, Ava, et al.
Publicado: (2022)

Cognitive appraisals of dissociation in psychosis: a new brief measure
por: Černis, Emma, et al.
Publicado: (2021)

Are young people with primary social anxiety disorder less likely to recover following generic CBT compared to young people with other primary anxiety disorders? A systematic review and meta-analysis
por: Evans, Rachel, et al.
Publicado: (2021)

Understanding agoraphobic avoidance: the development of the Oxford Cognitions and Defences Questionnaire (O-CDQ)
por: Rosebrock, Laina, et al.
Publicado: (2022)

Optimal perioperative care in peri-hilar cholangiocarcinoma resection
por: Quinn, Leonard M., et al.
Publicado: (2018)

Potential stressors in (prospective) physical education teachers: a comparison of different career stages
por: Pels, Fabian, et al.
Publicado: (2022)

Olfactory and taste dysfunction in coronavirus disease 2019 patients: its prevalence and outcomes
por: Jain, A, et al.
Publicado: (2020)

Remote psychophysical evaluation of olfactory and gustatory functions in early-stage coronavirus disease 2019 patients: the Bologna experience of 300 cases
por: Petrocelli, M, et al.
Publicado: (2020)

A concept for adapting medical education to the next generations via three-staged digital peer teaching key feature cases
por: Supper, Paul, et al.
Publicado: (2022)

Α Markov model for longitudinal studies with incomplete dichotomous outcomes
por: Efthimiou, Orestis, et al.
Publicado: (2016)

Misspecification of at‐risk periods and distributional assumptions in estimating COPD exacerbation rates: The resultant bias in treatment effect estimation
por: Law, M., et al.
Publicado: (2016)

Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data
por: Kunz, Cornelia Ursula, et al.
Publicado: (2014)

A proposal for a new PhD level curriculum on quantitative methods for drug development
por: Jaki, T., et al.
Publicado: (2018)

Dose‐escalation strategies which use subgroup information
por: Cotterill, Amy, et al.
Publicado: (2018)

Blinded continuous monitoring in clinical trials with recurrent event endpoints
por: Friede, Tim, et al.
Publicado: (2018)

On estimands and the analysis of adverse events in the presence of varying follow‐up times within the benefit assessment of therapies
por: Unkel, Steffen, et al.
Publicado: (2018)

Reference‐based sensitivity analysis for time‐to‐event data
por: Atkinson, Andrew, et al.
Publicado: (2019)

Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols
por: Häckl, Sebastian, et al.
Publicado: (2019)

A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations
por: Huber, Cynthia, et al.
Publicado: (2019)

Prior distributions for variance parameters in a sparse‐event meta‐analysis of a few small trials
por: Pateras, Konstantinos, et al.
Publicado: (2020)

Imputation of missing covariate in randomized controlled trials with a continuous outcome: Scoping review and new results
por: Kayembe, Mutamba T., et al.
Publicado: (2020)

Potential impact of COVID‐19 on ongoing clinical trials: a simulation study with the neurological Yale Global Tic Severity Scale based on the CANNA‐TICS study
por: Lasch, Florian, et al.
Publicado: (2021)

A robust permutation test for the concordance correlation coefficient
por: Hutson, Alan D., et al.
Publicado: (2021)

A comparison of reweighting estimators of average treatment effects in real world populations
por: Lin, Chen‐Yen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_724nbnmtp8hq78gvdocnm6a9b0