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Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, mainly characterised by the progressive loss of dopaminergic neurons. MPP(+) has been widely used as a PD-related neurotoxin, and their reports suggested the several hypotheses for neuronal cell death. However, most of these hypothe...

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Detalles Bibliográficos
Autores principales: Sakamoto, Shuichiro, Miyara, Masatsugu, Sanoh, Seigo, Ohta, Shigeru, Kotake, Yaichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405408/
https://www.ncbi.nlm.nih.gov/pubmed/28443637
http://dx.doi.org/10.1038/srep46668