Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

BACKGROUND: Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptide was successful in AD mouse models and led to removal of plaques and improved...

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Detalles Bibliográficos
Autores principales: Lambracht-Washington, Doris, Fu, Min, Frost, Pat, Rosenberg, Roger N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405538/
https://www.ncbi.nlm.nih.gov/pubmed/28441965
http://dx.doi.org/10.1186/s13195-017-0257-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405538/
https://www.ncbi.nlm.nih.gov/pubmed/28441965
http://dx.doi.org/10.1186/s13195-017-0257-7

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