Inclusion complexes of β-cyclodextrin with tricyclic drugs: an X-ray diffraction, NMR and molecular dynamics study

Tricyclic fused-ring cyclobenzaprine (1) and amitriptyline (2) form 1:1 inclusion complexes with β-cyclodextrin (β-CD) in the solid state and in water solution. Rotating frame NOE experiments (ROESY) showed the same geometry of inclusion for both 1/β-CD and 2/β-CD complexes, with the aromatic ring s...

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Detalles Bibliográficos
Autores principales: Castiglione, Franca, Ganazzoli, Fabio, Malpezzi, Luciana, Mele, Andrea, Panzeri, Walter, Raffaini, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405689/
https://www.ncbi.nlm.nih.gov/pubmed/28503206
http://dx.doi.org/10.3762/bjoc.13.70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405689/
https://www.ncbi.nlm.nih.gov/pubmed/28503206
http://dx.doi.org/10.3762/bjoc.13.70

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