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Chemical synthesis of RNA with site-specific methylphosphonate modifications
Methylphosphonate(mP)-modified RNA serves as valuable probe to evaluate biomolecular interactions between the nucleic acid backbone and binding partners, such as proteins or small molecules. Here, we describe an efficient workflow for the synthesis of RNA with a single mP modification in diastereome...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405801/ https://www.ncbi.nlm.nih.gov/pubmed/27037236 http://dx.doi.org/10.1016/j.ymeth.2016.03.024 |