Universal molecular screening does not effectively detect Lynch syndrome in clinical practice

BACKGROUND: Lynch syndrome (LS) due to an inherited damaging mutation in mismatch repair (MMR) genes comprises 3% of all incident colorectal cancer (CRC). Molecular testing using immunohistochemistry (IHC) for MMR proteins is a recommended screening tool to identify LS in incident CRC. This study as...

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Detalles Bibliográficos
Autores principales: Brennan, Beatrice, Hemmings, Christine T., Clark, Ian, Yip, Desmond, Fadia, Mitali, Taupin, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405883/
https://www.ncbi.nlm.nih.gov/pubmed/28491141
http://dx.doi.org/10.1177/1756283X17690990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405883/
https://www.ncbi.nlm.nih.gov/pubmed/28491141
http://dx.doi.org/10.1177/1756283X17690990

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