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Universal molecular screening does not effectively detect Lynch syndrome in clinical practice

BACKGROUND: Lynch syndrome (LS) due to an inherited damaging mutation in mismatch repair (MMR) genes comprises 3% of all incident colorectal cancer (CRC). Molecular testing using immunohistochemistry (IHC) for MMR proteins is a recommended screening tool to identify LS in incident CRC. This study as...

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Detalles Bibliográficos
Autores principales:	Brennan, Beatrice, Hemmings, Christine T., Clark, Ian, Yip, Desmond, Fadia, Mitali, Taupin, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405883/ https://www.ncbi.nlm.nih.gov/pubmed/28491141 http://dx.doi.org/10.1177/1756283X17690990

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