Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis

Venous thromboembolism is a complex disease with a high heritability. There are significant associations among Factor XI (FXI) levels and SNPs in the KNG1 and F11 loci. Our aim was to identify the genetic variation of KNG1 and F11 that might account for the variability of FXI levels. The KNG1 and F1...

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Detalles Bibliográficos
Autores principales: Martin-Fernandez, Laura, Gavidia-Bovadilla, Giovana, Corrales, Irene, Brunel, Helena, Ramírez, Lorena, López, Sonia, Souto, Juan Carlos, Vidal, Francisco, Soria, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405990/
https://www.ncbi.nlm.nih.gov/pubmed/28445521
http://dx.doi.org/10.1371/journal.pone.0176301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405990/
https://www.ncbi.nlm.nih.gov/pubmed/28445521
http://dx.doi.org/10.1371/journal.pone.0176301

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