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TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection

Establishing functional tissue-resident memory (T(RM)) cells at sites of infection is a newfound objective of T cell vaccine design. To directly assess the impact of antigen stimulation strength on memory CD8 T cell formation and function during a persistent viral infection, we created a library of...

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Detalles Bibliográficos
Autores principales: Maru, Saumya, Jin, Ge, Schell, Todd D., Lukacher, Aron E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406018/
https://www.ncbi.nlm.nih.gov/pubmed/28410427
http://dx.doi.org/10.1371/journal.ppat.1006318