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SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity
The heat shock response (HSR) is a well-conserved, cytoprotective stress response that activates the HSF1 transcription factor. During severe stress, cells inhibit mRNA splicing which also serves a cytoprotective function via inhibition of gene expression. Despite their functional interconnectedness...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406028/ https://www.ncbi.nlm.nih.gov/pubmed/28445500 http://dx.doi.org/10.1371/journal.pone.0176382 |