Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

Bacterial biofilms are associated with numerous human infections. The predominant protein expressed in enteric biofilms is the amyloid curli, which forms highly immunogenic complexes with DNA. Infection with curli-expressing bacteria or systemic exposure to purified curli-DNA complexes triggers auto...

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Detalles Bibliográficos
Autores principales: Tursi, Sarah A., Lee, Ernest Y., Medeiros, Nicole J., Lee, Michael H., Nicastro, Lauren K., Buttaro, Bettina, Gallucci, Stefania, Wilson, Ronald Paul, Wong, Gerard C. L., Tükel, Çagla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406031/
https://www.ncbi.nlm.nih.gov/pubmed/28410407
http://dx.doi.org/10.1371/journal.ppat.1006315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406031/
https://www.ncbi.nlm.nih.gov/pubmed/28410407
http://dx.doi.org/10.1371/journal.ppat.1006315

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