The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

Aging is attended by a progressive decline in protein homeostasis (proteostasis), aggravating the risk for protein aggregation diseases. To understand the coordination between proteome imbalance and longevity, we addressed the mechanistic role of the quality-control ubiquitin ligase CHIP, which is a...

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Detalles Bibliográficos
Autores principales: Tawo, Riga, Pokrzywa, Wojciech, Kevei, Éva, Akyuz, Melek E., Balaji, Vishnu, Adrian, Svenja, Höhfeld, Jörg, Hoppe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406386/
https://www.ncbi.nlm.nih.gov/pubmed/28431247
http://dx.doi.org/10.1016/j.cell.2017.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406386/
https://www.ncbi.nlm.nih.gov/pubmed/28431247
http://dx.doi.org/10.1016/j.cell.2017.04.003

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