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Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA(2) in Macrophages
Lysophosphatidic acid (LPA), one of the simplest phospholipid signaling molecules, participates in formation and disruption of atherosclerotic plaque. Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix (ECM) degradation and then thinnin...
Autores principales: | Gu, Chun, Wang, Fang, Zhao, Zhenwen, Wang, Hongyue, Cong, Xiangfeng, Chen, Xi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406459/ https://www.ncbi.nlm.nih.gov/pubmed/28496416 http://dx.doi.org/10.3389/fphys.2017.00266 |
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