Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

A degradation product of APOE ε4-encoded apolipoprotein E protein targets mitochondria and inhibits cytochrome oxidase (COX), and autopsy brains from young adult APOE ε4 carriers show reduced COX activity. To further explore relationships between APOE alleles and COX, we measured platelet mitochondr...

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Detalles Bibliográficos
Autores principales: Wilkins, Heather M., Koppel, Scott J., Bothwell, Rebecca, Mahnken, Jonathan, Burns, Jeffrey M., Swerdlow, Russell H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406545/
https://www.ncbi.nlm.nih.gov/pubmed/28448944
http://dx.doi.org/10.1016/j.redox.2017.04.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406545/
https://www.ncbi.nlm.nih.gov/pubmed/28448944
http://dx.doi.org/10.1016/j.redox.2017.04.010

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