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Influence of the estrus cycle on the evaluation of a vaginal irritation study in intact and ovariectomized rats
When conducting vaginal irritation studies, ovariectomized rats or rabbits are typically used according to practical reports. In the present study, we evaluated the influence of the estrus cycle in a vaginal irritation study using intact rats and ovariectomized rats, which exhibit a late diestrus-li...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Japanese Society of Toxicologic Pathology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406595/ https://www.ncbi.nlm.nih.gov/pubmed/28458454 http://dx.doi.org/10.1293/tox.2016-0059 |