Mitochondrial uncoupler exerts a synthetic lethal effect against β‐catenin mutant tumor cells

The wingless/int‐1 (Wnt) signal transduction pathway plays a central role in cell proliferation, survival, differentiation and apoptosis. When β‐catenin: a component of the Wnt pathway, is mutated into an active form, cell growth signaling is hyperactive and drives oncogenesis. As β‐catenin is mutat...

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Detalles Bibliográficos
Autores principales: Shikata, Yuki, Kiga, Masaki, Futamura, Yushi, Aono, Harumi, Inoue, Hiroyuki, Kawada, Manabu, Osada, Hiroyuki, Imoto, Masaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406605/
https://www.ncbi.nlm.nih.gov/pubmed/28107588
http://dx.doi.org/10.1111/cas.13172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406605/
https://www.ncbi.nlm.nih.gov/pubmed/28107588
http://dx.doi.org/10.1111/cas.13172

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