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PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts

The members of the PhosphoInositide-3 Kinase (PI3K) protein family are well-known regulators of proliferative signals. By the generation of lipid second messengers, they mediate the activation of AKT/PKB (AKT) and mammalian Target Of Rapamycin (mTOR) pathways. Although mutations in the PI3K/AKT/mTOR...

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Detalles Bibliográficos
Autores principales: De Santis, Maria Chiara, Sala, Valentina, Martini, Miriam, Ferrero, Giovanni Battista, Hirsch, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406705/
https://www.ncbi.nlm.nih.gov/pubmed/28353628
http://dx.doi.org/10.3390/cancers9040030