Cargando…

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts

The members of the PhosphoInositide-3 Kinase (PI3K) protein family are well-known regulators of proliferative signals. By the generation of lipid second messengers, they mediate the activation of AKT/PKB (AKT) and mammalian Target Of Rapamycin (mTOR) pathways. Although mutations in the PI3K/AKT/mTOR...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Santis, Maria Chiara, Sala, Valentina, Martini, Miriam, Ferrero, Giovanni Battista, Hirsch, Emilio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406705/ https://www.ncbi.nlm.nih.gov/pubmed/28353628 http://dx.doi.org/10.3390/cancers9040030

Ejemplares similares

How PI3K-derived lipids control cell division
por: Campa, Carlo C., et al.
Publicado: (2015)

Lateralized and Segmental Overgrowth in Children
por: Mussa, Alessandro, et al.
Publicado: (2021)

PI(3,4)P2 Signaling in Cancer and Metabolism
por: Gozzelino, Luca, et al.
Publicado: (2020)

Targeting PI3K in Cancer: Any Good News?
por: Martini, Miriam, et al.
Publicado: (2013)

Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases
por: Sala, Valentina, et al.
Publicado: (2021)

Hyper-activated PI3K-δ in immunodeficiency
por: Heurtier, Lucie, et al.
Publicado: (2015)

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation
por: Margaria, JP, et al.
Publicado: (2015)

LBL experiments T2K, T2KII, HyperK, HyperKK
por: di Lodovico, Francesca, et al.
Publicado: (2018)

hyperK start of construction
por: Aihara, Hiroaki
Publicado: (2018)

Cervical Mullerian Adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature
por: Patrelli, Tito Silvio, et al.
Publicado: (2011)

Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum
por: Koutlas, Ioannis G., et al.
Publicado: (2021)

Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum
por: Koutlas, Ioannis G., et al.
Publicado: (2020)

On the phase of $\eta _{\pm } =A(K_{L}\rightarrow \pi ^{+}\pi ^{-})/A(K_{S}\rightarrow \pi ^{+}\pi ^{-})$
por: Darriulat, Pierre, et al.
Publicado: (1969)

Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA
por: Choi, Heejin, et al.
Publicado: (2021)

Letter to editor: Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum
por: Maldonado, Andrés A., et al.
Publicado: (2022)

Clinical Response to PI3K-α Inhibition in a Cohort of Children and Adults With PIK3CA-Related Overgrowth Spectrum Disorders
por: Raghavendran, Prashant, et al.
Publicado: (2022)

Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer
por: Li, Huayi, et al.
Publicado: (2021)

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors
por: Galli, Ubaldina, et al.
Publicado: (2015)

The Overgrowth of Surgery in Gynæcology
Publicado: (1886)

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
por: Stark, Anne-Katrien, et al.
Publicado: (2018)

PI3K p110γ Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions
por: Zotes, Teresa M., et al.
Publicado: (2013)

Lateralized overgrowth with vascular malformation caused by a somatic PTPN11 pathogenic variant: Another piece added to the puzzle of mosaic RASopathies
por: Mussa, Alessandro, et al.
Publicado: (2022)

astrophysical neutrinos with DUNE and HyperK and JUNO
por: Gil Botella, Ines
Publicado: (2018)

The Hyper-K Underwater Electronics Assembly project
por: Botao, L, et al.
Publicado: (2023)

Amlodipine-induced gingival overgrowth
por: Triveni, M. G., et al.
Publicado: (2009)

Overgrowth of Rhodium on Gold Nanorods
por: Chantry, Ruth L., et al.
Publicado: (2012)

Papillomatous Overgrowth of Both Tonsils
por: Connor, F. Powell
Publicado: (1909)

Gingival overgrowth due to amlodipine
por: Krishnamoorthy, K.M., et al.
Publicado: (2016)

Overgrowth of Lactobacillus in gastric cancer
por: Li, Zhi-Peng, et al.
Publicado: (2021)

Impact of Hyper- and Hypo-Uricemia on Kidney Function
por: Miake, Junichiro, et al.
Publicado: (2023)

Chemical Oral Cancerogenesis Is Impaired in PI3Kγ Knockout and Kinase-Dead Mice
por: Berta, Giovanni Nicolao, et al.
Publicado: (2021)

Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects
por: Jhamnani, Rekha D., et al.
Publicado: (2018)

PI3K Signaling in Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and Acute Lung Injury
por: Margaria, Jean Piero, et al.
Publicado: (2022)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Clinical implications of airway hyper-responsiveness in COPD
por: Scichilone, Nicola, et al.
Publicado: (2006)

The investigation of $K^+\pi^−, \pi^+K^−$ and $\pi^+\pi^−$ atoms
por: Yazkov, Valeriy
Publicado: (2016)

Preliminary Studies of Prostatic Overgrowth by Projectometry
por: Woods, Francis M.
Publicado: (1933)

Mullerian Adenosarcoma of the Uterus with Sarcomatous Overgrowth
por: Singh, Reecha, et al.
Publicado: (2010)

Genetic syndromes associated with overgrowth in childhood
por: Ko, Jung Min
Publicado: (2013)

Overgrowth Syndromes—Evaluation, Diagnosis, and Management
por: Manor, Joshua, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cseb7dfn23gh8dinpqqgvo1jqq