Cargando…

NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations

By physically interacting with beta-1 integrins, the NG2 proteoglycan enhances activation of the integrin heterodimers. In glioma cells, co-localization of NG2 and α3β1 integrin in individual cells (cis interaction) can be demonstrated by immunolabeling, and the NG2-integrin interaction can be confi...

Descripción completa

Detalles Bibliográficos
Autor principal:	Stallcup, William B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406706/ https://www.ncbi.nlm.nih.gov/pubmed/28362324 http://dx.doi.org/10.3390/cancers9040031

Ejemplares similares

NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function
por: You, Weon-Kyoo, et al.
Publicado: (2013)

NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair
por: Kucharova, Karolina, et al.
Publicado: (2015)

NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization
por: Yotsumoto, Fusanori, et al.
Publicado: (2015)

Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration
por: Makagiansar, Irwan T., et al.
Publicado: (2007)

Distinct NG2 proteoglycan-dependent roles of resident microglia and bone marrow-derived macrophages during myelin damage and repair
por: Kucharova, Karolina, et al.
Publicado: (2017)

Ablation of NG2 Proteoglycan Leads to Deficits in Brown Fat Function and to Adult Onset Obesity
por: Chang, Yunchao, et al.
Publicado: (2012)

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility
por: Feutlinske, Fabian, et al.
Publicado: (2015)

The Role of NG2 Proteoglycan in Glioma
por: Yadavilli, Sridevi, et al.
Publicado: (2016)

Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage
por: Hsu, Shu-Hsuan Claire, et al.
Publicado: (2018)

NgR1 and NgR3 are Receptors for Chondroitin Sulfate Proteoglycans
por: Dickendesher, Travis L., et al.
Publicado: (2012)

Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2
por: Huang, Wenhui, et al.
Publicado: (2020)

Pathology-induced NG2 proteoglycan expression in microglia
por: Meyer, Erika, et al.
Publicado: (2022)

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
por: Gibby, Krissa, et al.
Publicado: (2012)

Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan
por: Leoni, Giampaolo, et al.
Publicado: (2014)

Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
por: ABDEL-HAKIEM, Mohammed, et al.
Publicado: (2015)

Theranostic Impact of NG2/CSPG4 Proteoglycan in Cancer
por: Nicolosi, Pier Andrea, et al.
Publicado: (2015)

Thy-1-Integrin Interactions in cis and Trans Mediate Distinctive Signaling
por: Hu, Ping, et al.
Publicado: (2022)

The primary structure of NG2, a novel membrane-spanning proteoglycan
Publicado: (1991)

Interaction of the NG2 chondroitin sulfate proteoglycan with type VI collagen
Publicado: (1990)

PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2
por: Terrile, Marta, et al.
Publicado: (2010)

Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan
por: Albrecht, Stefanie, et al.
Publicado: (2016)

HIV-1 Tat and Heparan Sulfate Proteoglycans Orchestrate the Setup of in Cis and in Trans Cell-Surface Interactions Functional to Lymphocyte Trans-Endothelial Migration
por: Urbinati, Chiara, et al.
Publicado: (2021)

Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration
por: Soares, Mariana A., et al.
Publicado: (2015)

Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects
por: Müller, Daria, et al.
Publicado: (2021)

Correction: Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan
Publicado: (2018)

Cis and trans effects differentially contribute to the evolution of promoters and enhancers
por: Mattioli, Kaia, et al.
Publicado: (2020)

Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons
por: Belachew, Shibeshih, et al.
Publicado: (2003)

Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse
por: Hossain-Ibrahim, Mohammed K, et al.
Publicado: (2007)

Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
por: Kucharova, Karolina, et al.
Publicado: (2011)

Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas
por: Mellai, Marta, et al.
Publicado: (2020)

LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms
por: Carmona, Sarah, et al.
Publicado: (2018)

Human gene regulatory evolution is driven by the divergence of regulatory element function in both cis and trans
por: Hansen, Tyler, et al.
Publicado: (2023)

Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma
por: Wang, Jian, et al.
Publicado: (2011)

Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
por: Schultz, Nina, et al.
Publicado: (2014)

NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor
por: Brand, Caroline, et al.
Publicado: (2016)

Coordinate Regulation of Cadherin and Integrin Function by the Chondroitin Sulfate Proteoglycan Neurocan
por: Li, Hedong, et al.
Publicado: (2000)

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA
por: Li, Shi-Yuan, et al.
Publicado: (2018)

Cis- and trans-regulation in X inactivation
por: van Bemmel, Joke G., et al.
Publicado: (2015)

Relative Stability of cis- and trans-Hydrindanones
por: Tori, Motoo
Publicado: (2015)

Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_j4sf1a13092gsmvdtjtolmrju9